The potential role of functional inhibition of T regulatory cells by anti-TGF-beta antibody in photodynamic therapy of renal cancer

Pawel Mroz; Michael R. Hamblin

doi:10.1117/12.876523

8 February 2011 The potential role of functional inhibition of T regulatory cells by anti-TGFβ antibody in photodynamic therapy of renal cancer

Pawel Mroz, Michael R. Hamblin

Author Affiliations +

Proceedings Volume 7900, Biophotonics and Immune Responses VI; 790003 (2011) https://doi.org/10.1117/12.876523
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Photodynamic therapy (PDT) has been shown to be an effective locally ablative anti-cancer treatment that has the additional advantage of inducing tumor-directed immune response. We hypothesized that PDT could be combined with anti-transforming growth factor (TGF) beta antibody that does not significantly affect the population of cytotoxic T lymphocytes (CTL) but at the same time, has the potential to decrease the immunosuppressive effects of regulatory T-cells (Treg) mediated by TGF beta. This hypothesis was tested with aTGF-beta antibody combined with BPD-mediated PDT in a BALB/c renal cell carcinoma model. Evidence of positive benefits of the combination therapy over individual treatments alone was obtained.

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Pawel Mroz and Michael R. Hamblin "The potential role of functional inhibition of T regulatory cells by anti-TGFβ antibody in photodynamic therapy of renal cancer", Proc. SPIE 7900, Biophotonics and Immune Responses VI, 790003 (8 February 2011); https://doi.org/10.1117/12.876523

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