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23 February 2011 Hepatic ablation with multiple interstitial ultrasound applicators: initial ex vivo and computational studies
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Abstract
Radiofrequency (RF) ablation has emerged as an effective method for treating liver tumors under 3 cm in diameter. Multiple applicator devices and techniques - using RF, microwave and other modalities - are under development for thermal ablation of large and irregularly-shaped liver tumors. Interstitial ultrasound (IUS) applicators, comprised of linear arrays of independently powered tubular transducers, enable 3D control of the spatial power deposition profile and simultaneous ablation with multiple applicators. We evaluated IUS applicator configurations (parallel, converging and diverging implants) suitable for percutaneous and laparascopic placement with experiments in ex vivo bovine tissue and computational models. Ex vivo ablation zones measured 4.6±0.5 x 4.2±0.5 × 3.3±0.5 cm3 and 5.6±0.5 × 4.9±0.5 x 2.8±0.3 cm3 using three parallel applicators spaced 2 and 3 cm apart, respectively, and 4.0±0.3 × 3.2±0.4 × 2.9±0.2 cm3 using two parallel applicators spaced 2 cm apart. Computational models indicate in vivo ablation zones up to 4.5 × 4.4 × 5.5 cm3 and 5.7 × 4.8 × 5.2 cm3, using three applicators spaced 2 and 3 cm apart, respectively. Converging and diverging implant patterns can also be employed for conformal ablation of irregularly-shaped tumor margins by tailoring power levels along each device. Simultaneously powered interstitial ultrasound devices can create tailored ablation zones comparable to currently available RF devices and similarly sized microwave antennas.
© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Punit Prakash, Vasant A. Salgaonkar, E. Clif Burdette, and Chris J. Diederich "Hepatic ablation with multiple interstitial ultrasound applicators: initial ex vivo and computational studies", Proc. SPIE 7901, Energy-based Treatment of Tissue and Assessment VI, 79010R (23 February 2011); https://doi.org/10.1117/12.876522
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