Electrical property-based biopsy for prostate cancer detection and assessment

Ryan J. Halter; Vaishali Mishra; Hamza Bouayad; Preston Manwaring; John Heaney; Alan Schned

doi:10.1117/12.876489

23 February 2011 Electrical property-based biopsy for prostate cancer detection and assessment

Ryan J. Halter, Vaishali Mishra, Hamza Bouayad, Preston Manwaring, John Heaney, Alan Schned

Proceedings Volume 7901, Energy-based Treatment of Tissue and Assessment VI; 79010U (2011) https://doi.org/10.1117/12.876489
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Prostate cancer diagnosis is based solely on biopsy-based findings. Unfortunately, routine biopsy protocols only sample ~0.95% of the entire gland limiting the technique's sensitivity to cancer detection. Previous studies have demonstrated significant electrical property differences between malignant and benign prostate tissues due to their dissimilar morphological architectures. We have taken the important step of translating these findings to the clinic by integrating an electrical property sensor into the tip of a standard biopsy needle. This novel device allows clinicians to simultaneously extract a tissue core and assess the electrical properties around the needle tip in real-time. The expected volume of tissue sensed with this device was estimated using finite-element method (FEM) based simulations to model the potential fields and current distributions. Prototype devices have been constructed and evaluated in a series of saline baths in order to validate the FEM-based findings. Simulations suggest that the electrical property sensor is able to interrogate a tissue volume of ~62.1 mm³ and experimental results demonstrated a volume of sensitivity of ~68.7 mm³. This coupled device is being used to assess the increased sensitivity and specificity to cancer detection when electrical properties are sensed in concert with tissue core extraction in a series of 50 ex vivo prostates. Typical 12-core prostate biopsy protocols extract a total tissue volume of 228 mm³ for histological assessment. Employing this electrical property sensor to gauge electrical properties at both the beginning and end of the needle trajectory will provide pathological assessment of an additional 1648 mm³ of tissue.

Citation Download Citation

Ryan J. Halter, Vaishali Mishra, Hamza Bouayad, Preston Manwaring, John Heaney, and Alan Schned "Electrical property-based biopsy for prostate cancer detection and assessment", Proc. SPIE 7901, Energy-based Treatment of Tissue and Assessment VI, 79010U (23 February 2011); https://doi.org/10.1117/12.876489

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