23 February 2011 Dual thermal ablation modality of solid tumors in a mouse model
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Purpose: Develop a new combination therapy consisting of cryoablation and conductive high-temperature ablation for enhanced thermal ablation of solid tumors. Methods: We have constructed an invasive probe that can be used for consecutive cryoablation and hightemperature ablation (C/HTA), with a single insertion. The C/HTA probe was tested, in Balb/c mice bearing solid 4T1 tumors, in comparison to cryoablation and high temperature ablation, only. Three days after ablation, the diameter of the ablated zone was evaluated with pathological examination. Results: The C/HTA device can be used to induce larger ablation zones, in comparison to high temperature or cryoablation alone, and at lower thermal doses and temperatures than either modality alone. Conclusions: The relatively high thermal conductivity of ice, in comparison to water and native tissue, enables rapid heating of the ice-ball that result in improved conductive high temperature ablation. The new dual thermal modality improves ablation outcomes at lower thermal doses in comparison to a single ablation modality.
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Gal Shafirstein, Gal Shafirstein, Klressa Barnes, Klressa Barnes, Leah Hennings, Leah Hennings, Jessica Webber, Jessica Webber, Eduardo G. Moros, Eduardo G. Moros, Beata Przybyla, Beata Przybyla, Robert J. Griffin, Robert J. Griffin, "Dual thermal ablation modality of solid tumors in a mouse model", Proc. SPIE 7901, Energy-based Treatment of Tissue and Assessment VI, 79010Z (23 February 2011); doi: 10.1117/12.876427; https://doi.org/10.1117/12.876427

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