Purpose: Develop a new combination therapy consisting of cryoablation and conductive high-temperature
ablation for enhanced thermal ablation of solid tumors.
Methods: We have constructed an invasive probe that can be used for consecutive cryoablation and hightemperature
ablation (C/HTA), with a single insertion. The C/HTA probe was tested, in Balb/c mice bearing
solid 4T1 tumors, in comparison to cryoablation and high temperature ablation, only. Three days after
ablation, the diameter of the ablated zone was evaluated with pathological examination.
Results: The C/HTA device can be used to induce larger ablation zones, in comparison to high temperature or
cryoablation alone, and at lower thermal doses and temperatures than either modality alone.
Conclusions: The relatively high thermal conductivity of ice, in comparison to water and native tissue,
enables rapid heating of the ice-ball that result in improved conductive high temperature ablation. The new
dual thermal modality improves ablation outcomes at lower thermal doses in comparison to a single ablation