Arrhenius parameters for primary thermal injury in human tonsillar tissue

Kathleen McMillan; Rebecca Radabaugh; James E. Coad

doi:10.1117/12.876338

22 February 2011 Arrhenius parameters for primary thermal injury in human tonsillar tissue

Kathleen McMillan, Rebecca Radabaugh, James E. Coad

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Proceedings Volume 7901, Energy-based Treatment of Tissue and Assessment VI; 790110 (2011) https://doi.org/10.1117/12.876338
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Clinical implementation of a thermal therapy requires the ability to predict tissue injury following exposures to specific thermal histories. As part of an effort to develop a nonexcisional alternative to tonsillectomy, the degree of primary hyperthermic tissue injury in human tonsil was characterized. Fifteen fresh pediatric hypertrophic tonsillectomy specimens were sectioned and treated in a NIST-calibrated saline bath at temperatures of 40 to 70°C with hold times of one to seven minutes. The treated tissues were subsequently nitroblue tetrazolium (NBT) stained to assess for thermal respiratory enzyme inactivation as a marker of cellular injury/death. The NBT stains were quantitatively image analyzed and used to calculate Arrhenius parameters for primary thermal injury in human tonsils.

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Kathleen McMillan, Rebecca Radabaugh, and James E. Coad "Arrhenius parameters for primary thermal injury in human tonsillar tissue", Proc. SPIE 7901, Energy-based Treatment of Tissue and Assessment VI, 790110 (22 February 2011); https://doi.org/10.1117/12.876338

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KEYWORDS

Tissues

Injuries

Image analysis

Matrices

Natural surfaces

RGB color model

Thermal modeling

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