22 February 2011 Arrhenius parameters for primary thermal injury in human tonsillar tissue
Author Affiliations +
Abstract
Clinical implementation of a thermal therapy requires the ability to predict tissue injury following exposures to specific thermal histories. As part of an effort to develop a nonexcisional alternative to tonsillectomy, the degree of primary hyperthermic tissue injury in human tonsil was characterized. Fifteen fresh pediatric hypertrophic tonsillectomy specimens were sectioned and treated in a NIST-calibrated saline bath at temperatures of 40 to 70°C with hold times of one to seven minutes. The treated tissues were subsequently nitroblue tetrazolium (NBT) stained to assess for thermal respiratory enzyme inactivation as a marker of cellular injury/death. The NBT stains were quantitatively image analyzed and used to calculate Arrhenius parameters for primary thermal injury in human tonsils.
© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Kathleen McMillan, Kathleen McMillan, Rebecca Radabaugh, Rebecca Radabaugh, James E. Coad, James E. Coad, } "Arrhenius parameters for primary thermal injury in human tonsillar tissue", Proc. SPIE 7901, Energy-based Treatment of Tissue and Assessment VI, 790110 (22 February 2011); doi: 10.1117/12.876338; https://doi.org/10.1117/12.876338
PROCEEDINGS
13 PAGES


SHARE
Back to Top