11 February 2011 Retention of indocyanine green as a potential marker for optical detection of blood brain barrier disruption
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Abstract
Preliminary studies have shown that there is great variability in the degree of disruption of blood-brain barrier (BBBD) after the intraarterial injection of mannitol in rabbit models. The disruption of blood-brain barrier (BBB) is affected by a number of factors, and the variations could have a profound impact on regional delivery of chemotherapeutics. Optically measured brain tissue concentrations of indocyanine green (ICG) and Evan's blue (EB) enable the quantification of BBBD after intraarterial administration of mannitol. Using the optical pharmacokinetics technique, a variation of diffuse reflectance spectroscopy, we are able to track in vivo brain tissue concentrations of ICG and EB in rabbits, before and after barrier disruption. This study shows the feasibility of optical monitoring of BBBD, a method that can help improve intraarterial delivery of chemotherapeutic drugs.
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A. Ergin, A. Ergin, S. Joshi, S. Joshi, M. Wang, M. Wang, I. J. Bigio, I. J. Bigio, } "Retention of indocyanine green as a potential marker for optical detection of blood brain barrier disruption", Proc. SPIE 7907, Biomedical Applications of Light Scattering V, 79070L (11 February 2011); doi: 10.1117/12.875405; https://doi.org/10.1117/12.875405
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