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11 February 2011Intrinsic optical signal imaging of glucose-stimulated physiological
responses in the insulin secreting INS-1 β-cell line
Intrinsic optical signal (IOS) imaging has been established for noninvasive monitoring of stimulus-evoked physiological
responses in the retina and other neural tissues. Recently, we extended the IOS imaging technology for functional
evaluation of insulin secreting INS-1 cells. INS-1 cells provide a popular model for investigating β-cell dysfunction and
diabetes. Our experiments indicate that IOS imaging allows simultaneous monitoring of glucose-stimulated
physiological responses in multiple cells with high spatial (sub-cellular) and temporal (sub-second) resolution. Rapid
image sequences reveal transient optical responses that have time courses comparable to glucose-evoked β-cell electrical
activities.
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Yi-Chao Li, Wan-Xing Cui, Xu-Jing Wang, Franklin Amthor, Xin-Cheng Yao, "Intrinsic optical signal imaging of glucose-stimulated physiological responses in the insulin secreting INS-1 β-cell line," Proc. SPIE 7907, Biomedical Applications of Light Scattering V, 79070Y (11 February 2011); https://doi.org/10.1117/12.874989