11 February 2011 Bridging the fields of nanoscience and toxicology: nanoparticle impact on biological models
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Abstract
In the emerging area of nanotechnology a key issue is related to the potential impacts of the novel nanomaterials on the environment and human health so that this technology can be used with minimal risk. Specifically designed to combine on a single structure multipurpose tags and properties, nanomaterials need a comprehensive characterization of both chemicophysical properties and toxicological evaluation, which is a challenging endeavor: the in vitro toxicity assays that are employed for nanotoxicity assessments do not accurately predict in vivo response. To overcome these limitations and gain a deeper understanding of nanoparticle-cell interactions, we have employed cnidarian models, in particular the freshwater polyp Hydra vulgaris, not opposed to more complex and evoluted systems, but to add valuable information, at an intermediate level between prokaryotes and vertebrates, on both cytoxicity and on pollution affecting the environment. By testing CdSe/CdS core shell nanocrystals in vivo, at whole animal level, we investigated the impact of their properties on uptake, accumulation, biodistribution, elicitation of behavioural responses. Spanning from animal to cell biology, we provide an analysis on metal based and semiconductor NC, discussing the crucial role played by the synthesis route and chemical surface on the toxicity for living organisms.
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A. Ambrosone, A. Ambrosone, V. Marchesano, V. Marchesano, L. Mattera, L. Mattera, A. Tino, A. Tino, C. Tortiglione, C. Tortiglione, } "Bridging the fields of nanoscience and toxicology: nanoparticle impact on biological models", Proc. SPIE 7909, Colloidal Quantum Dots/Nanocrystals for Biomedical Applications VI, 79090B (11 February 2011); doi: 10.1117/12.874494; https://doi.org/10.1117/12.874494
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