11 February 2011 In vivo monitoring of organ-selective distribution of CdHgTe/SiO2 nanoparticles in mouse model
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Abstract
CdHgTe/SiO2 nanoparticles were prepared by SiO2 capping on the surface of CdHgTe quantum dots (QDs). The characteristics, such as optical spectra, size and optical stability were investigated. The size of CdHgTe/SiO2 nanoparticles could be larger than 100 nm after CdHgTe QDs capped with SiO2. CdHgTe/SiO2 nanoparticles acted as a novel fluorescence probe have a maximum fluorescence emission of 790 nm and a full width at half-maximum (FWHM) of 50-70 nm. The in vivo fluorescence imaging of CdHgTe/SiO2 nanoparticles in mouse model indicated the nanoparticles could be passively targeting to lung and liver. CdHgTe/SiO2 nanoparticles offer new perspectives for size dependent bio-dstribution studies in living body.
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Haiyan Chen, Sisi Cui, Hongyan Zhu, Zhenzhen Tu, Lingling Shan, Jianpeng Xue, Dawei Deng, Jun Zhang, Yueqing Gu, "In vivo monitoring of organ-selective distribution of CdHgTe/SiO2 nanoparticles in mouse model", Proc. SPIE 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, 79100S (11 February 2011); doi: 10.1117/12.873350; https://doi.org/10.1117/12.873350
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