11 February 2011 Novel design of multimodal MRI/NIR optical contrast agent
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We present a novel, dual modality gadolinium based MRI/near-infrared optical probe. Utilizing a fluorescent dye as a scaffold with attached Gd-chelating moiety, we demonstrated a substantial shortening of T1 relaxation time of water protons in vitro. The probe was compared to the commonly used MRI Gd-based contrast agents Magnevist® and Multihance® and showed superior contrast properties. The enhancement was due to strong albumin binding of the hydrophobic fluorophore and overall rigidification of the contrast agent. Due to the near-infrared optical properties of the probe and excellent MRI activity the proposed construct can be potentially utilized as a dual probe in multimodal MRI/NIR optical imaging.
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Kevin Guo, Kevin Guo, Franck Lin, Franck Lin, Walter Akers, Walter Akers, Jie Zheng, Jie Zheng, Bao Teng, Bao Teng, Olga Vasalatiy, Olga Vasalatiy, Gary L. Griffiths, Gary L. Griffiths, Amir Gandjbakhche, Amir Gandjbakhche, Mikhail Y. Berezin, Mikhail Y. Berezin, Samuel Achilefu, Samuel Achilefu, "Novel design of multimodal MRI/NIR optical contrast agent", Proc. SPIE 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, 791015 (11 February 2011); doi: 10.1117/12.881395; https://doi.org/10.1117/12.881395

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