11 February 2011 Quantitative in vivo lifetime imaging using a time-domain platform with a supercontinuum tunable laser for extended spectral coverage
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Abstract
The continuously expanding number of fluorescent probes developed for molecular imaging in vivo requires new instruments, more flexible and with higher quantification power. Responding to those requirements we propose a new instrument: it combines the sensitivity of time correlated single photon detection with the extended spectral coverage of a pulsed supercontinuum laser in a sensitive and flexible time-domain platform for in vivo molecular imaging in small animals. The performance of the system is demonstrated on a case study, using NEO-STEM-PMSR50- PEG fluorescent silica nanoprobes and sequential imaging of CD-1 nude mice.
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Niculae Mincu, Dao Chao Huang, Marilyse Piche, Guobin Ma, "Quantitative in vivo lifetime imaging using a time-domain platform with a supercontinuum tunable laser for extended spectral coverage", Proc. SPIE 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, 79101K (11 February 2011); doi: 10.1117/12.875214; https://doi.org/10.1117/12.875214
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