Development of a molecularly imprinted polymer-based surface plasmon resonance sensor for theophylline monitoring

Rui Zheng; Brent D. Cameron

doi:10.1117/12.875312

12 February 2011 Development of a molecularly imprinted polymer based surface plasmon resonance sensor for theophylline monitoring

Rui Zheng, Brent D. Cameron

Author Affiliations +

Proceedings Volume 7911, Plasmonics in Biology and Medicine VIII; 79110F (2011) https://doi.org/10.1117/12.875312
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Molecularly imprinted polymer (MIP) thin films and surface plasmon resonance (SPR) sensing technologies were combined to develop a novel sensing platform for monitoring real-time theophylline concentration, which is a compound of interest in environmental monitoring and a molecular probe for phenotyping certain cytochrome P450 enzymes. The MIPs hydrogel is easy to synthesize and provides shape-selective recognition with high affinity to specific target molecules. Different polymerization formulas were tested and optimized. The influence of the monomer sensitive factors were addressed by SPR. SPR is an evanescent wave optics based sensing technique that is suitable for real-time and label free sensing purposes. Gold nanorods (Au NRs) were uniformly immobilized onto a SPR sensing surface for the construction of a fiber optics based prism-free localized SPR (LSPR) measurement. This technique can be also applied to assess the activities of other small organic molecules by adjusting the polymerization formula, thus, this approach also has many other potential applications.

Citation Download Citation

Rui Zheng and Brent D. Cameron "Development of a molecularly imprinted polymer based surface plasmon resonance sensor for theophylline monitoring", Proc. SPIE 7911, Plasmonics in Biology and Medicine VIII, 79110F (12 February 2011); https://doi.org/10.1117/12.875312

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available