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11 February 2011 Integrated lab-on-a-chip: a combined sample preparation and PCR system as an ultrafast analytical tool for pathogen detection
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Abstract
Lab-on-a-chip systems are seen as a very promising approach for a decentralized continuous pathogen monitoring technology. In this paper, we present the development of a fully integrated device for the multiplexed nucleic-acid based identification of pathogens. Due to the complexity of such a fully integrated device, in a first development step, functional modules for the various process steps like lysis, DNA extraction and purification, continuous-flow PCR and detection have been developed and evaluated, allowing a functional verification prior to integration. All the modules as well as the final integrated device have been manufactured using scaleable industrial manufacturing methods, namely injection molding in order to facilitate commercialization.
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Holger Becker, Nadine Hlawatsch, Richard Klemm, and Claudia Gärtner "Integrated lab-on-a-chip: a combined sample preparation and PCR system as an ultrafast analytical tool for pathogen detection", Proc. SPIE 7929, Microfluidics, BioMEMS, and Medical Microsystems IX, 792903 (11 February 2011); doi: 10.1117/12.874551; https://doi.org/10.1117/12.874551
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