14 February 2011 Nanoplasmonics as nanofluidics: transport and sensing in flowthrough nanohole arrays
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Abstract
Metallic nanohole arrays support surface electromagnetic waves that enable enhanced optical transmission and may be exploited for sensing. Our group has been active in the application of enhanced optical transmission to chemical and biological sensing, and in the optofluidic integration nanohole arrays. Our recent work in this area is described here. Our research on the combined photonic and fluidic characteristics of flow-through nanohole arrays and their application to sensing is presented. Flow-through nanohole arrays provide a biomarker sieving capacity that is unique among plasmonic sensors as well as rapid transport of reactants to the sensing surface. Our experiments indicate a order of magnitude improvement in sensor response time for flow-through operation as compared to current flow-over sensing methods. Transport analysis results indicate that more than a 20-fold improvement may be expected for small biomolecules with rapid reaction kinetics.
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Carlos Escobedo, Carlos Escobedo, Alexandre G. Brolo, Alexandre G. Brolo, Reuven Gordon, Reuven Gordon, David Sinton, David Sinton, } "Nanoplasmonics as nanofluidics: transport and sensing in flowthrough nanohole arrays", Proc. SPIE 7929, Microfluidics, BioMEMS, and Medical Microsystems IX, 79290Q (14 February 2011); doi: 10.1117/12.875848; https://doi.org/10.1117/12.875848
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