14 February 2011 PharmaSat: drug dose response in microgravity from a free-flying integrated biofluidic/optical culture-and-analysis satellite
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Abstract
We designed, built, tested, space-qualified, launched, and collected telemetered data from low Earth orbit from Pharma- Sat, a 5.1-kg free flying "nanosatellite" that supported microbial growth in 48 microfluidic wells, dosed microbes with multiple concentrations of a pharmaceutical agent, and monitored microbial growth and metabolic activity using a dedicated 3-color optical absorbance system at each microwell. The PharmaSat nanosatellite comprised a structure approximately 10 x 10 x 35 cm, including triple-junction solar cells, bidirectional communications, power-generation and energy- storage system, and a sealed payload 1.2-L containment vessel that housed the biological organisms along with the fluidic, optical, thermal, sensor, and electronic subsystems. Growth curves for S. cerevisiae (Brewer's yeast) were obtained for multiple concentrations of the antifungal drug voriconazole in the microgravity conditions of low Earth orbit. Corresponding terrestrial control experiments were conducted for comparison.
© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Antonio J. Ricco, Antonio J. Ricco, Macarena Parra, Macarena Parra, David Niesel, David Niesel, Matthew Piccini, Matthew Piccini, Diana Ly, Diana Ly, Michael McGinnis, Michael McGinnis, Andrzej Kudlicki, Andrzej Kudlicki, John W. Hines, John W. Hines, Linda Timucin, Linda Timucin, Chris Beasley, Chris Beasley, Robert Ricks, Robert Ricks, Michael McIntyre, Michael McIntyre, Charlie Friedericks, Charlie Friedericks, Michael Henschke, Michael Henschke, Ricky Leung, Ricky Leung, Millan Diaz-Aguado, Millan Diaz-Aguado, Christopher Kitts, Christopher Kitts, Ignacio Mas, Ignacio Mas, Mike Rasay, Mike Rasay, Elwood Agasid, Elwood Agasid, Ed Luzzi, Ed Luzzi, Karolyn Ronzano, Karolyn Ronzano, David Squires, David Squires, Bruce Yost, Bruce Yost, } "PharmaSat: drug dose response in microgravity from a free-flying integrated biofluidic/optical culture-and-analysis satellite", Proc. SPIE 7929, Microfluidics, BioMEMS, and Medical Microsystems IX, 79290T (14 February 2011); doi: 10.1117/12.881082; https://doi.org/10.1117/12.881082
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