15 February 2011 A MEMS ultrasonic sensor design for early detection of ovarian cancer
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Proceedings Volume 7929, Microfluidics, BioMEMS, and Medical Microsystems IX; 79290X (2011); doi: 10.1117/12.874718
Event: SPIE MOEMS-MEMS, 2011, San Francisco, California, United States
Abstract
In this study, we investigate a simple, disposable, low-cost, ultrasensitive, and fully-integrated biosensor chip for early ovarian cancer detection. The proposed sensor quantifies urinary anti-apoptotic protein Bcl-2 level that is elevated at various stages of ovarian cancer. Our approach utilizes MEMS ultrasonic transducers that have been demonstrated to be advantageous when compared to piezoelectric transducers. Piezoelectric transducers are expensive, bioincompatible (contain lead), and cannot be integrated in a fully-packaged chip. More importantly, these transducers lack the sensitivity required for early ovarian cancer detection, expensive, not biocompatible (contains Lead) and cannot be integrated for a fully-packaged chip. Our experimentally verified simulations indicate 0.15 pg/ml mass sensitivity with our sensor.
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Onursal Onen, Patricia Kruk, Rasim Guldiken, "A MEMS ultrasonic sensor design for early detection of ovarian cancer", Proc. SPIE 7929, Microfluidics, BioMEMS, and Medical Microsystems IX, 79290X (15 February 2011); doi: 10.1117/12.874718; http://dx.doi.org/10.1117/12.874718
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KEYWORDS
Ovarian cancer

Sensors

Transducers

Biosensors

Electrodes

Proteins

Ultrasonics

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