In this study, we investigate a simple, disposable, low-cost, ultrasensitive, and fully-integrated biosensor chip for early
ovarian cancer detection. The proposed sensor quantifies urinary anti-apoptotic protein Bcl-2 level that is elevated at
various stages of ovarian cancer. Our approach utilizes MEMS ultrasonic transducers that have been demonstrated to be
advantageous when compared to piezoelectric transducers. Piezoelectric transducers are expensive, bioincompatible
(contain lead), and cannot be integrated in a fully-packaged chip. More importantly, these transducers lack the sensitivity
required for early ovarian cancer detection, expensive, not biocompatible (contains Lead) and cannot be integrated for a
fully-packaged chip. Our experimentally verified simulations indicate 0.15 pg/ml mass sensitivity with our sensor.