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14 February 2011 A MEMS ultrasonic sensor design for early detection of ovarian cancer
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Abstract
In this study, we investigate a simple, disposable, low-cost, ultrasensitive, and fully-integrated biosensor chip for early ovarian cancer detection. The proposed sensor quantifies urinary anti-apoptotic protein Bcl-2 level that is elevated at various stages of ovarian cancer. Our approach utilizes MEMS ultrasonic transducers that have been demonstrated to be advantageous when compared to piezoelectric transducers. Piezoelectric transducers are expensive, bioincompatible (contain lead), and cannot be integrated in a fully-packaged chip. More importantly, these transducers lack the sensitivity required for early ovarian cancer detection, expensive, not biocompatible (contains Lead) and cannot be integrated for a fully-packaged chip. Our experimentally verified simulations indicate 0.15 pg/ml mass sensitivity with our sensor.
© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Onursal Onen, Patricia Kruk, and Rasim Guldiken "A MEMS ultrasonic sensor design for early detection of ovarian cancer", Proc. SPIE 7929, Microfluidics, BioMEMS, and Medical Microsystems IX, 79290X (14 February 2011); https://doi.org/10.1117/12.874718
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