Terahertz time-lapse imaging of hydration in physiological tissues

David B. Bennett; Zachary D. Taylor; Neha Bajwa; Priyamvada Tewari; Ashkan Maccabi; Shijun Sung; Rahul S. Singh; Martin O. Culjat; Warren S. Grundfest; Elliott R. Brown

doi:10.1117/12.882962

23 February 2011 Terahertz time-lapse imaging of hydration in physiological tissues

David B. Bennett, Zachary D. Taylor, Neha Bajwa, Priyamvada Tewari, Ashkan Maccabi, Shijun Sung, Rahul S. Singh, Martin O. Culjat, Warren S. Grundfest, Elliott R. Brown

Author Affiliations +

Proceedings Volume 7938, Terahertz Technology and Applications IV; 793808 (2011) https://doi.org/10.1117/12.882962
Event: SPIE OPTO, 2011, San Francisco, California, United States

Abstract

This study describes terahertz (THz) imaging of hydration changes in physiological tissues with high water concentration sensitivity. A fast-scanning, pulsed THz imaging system (centered at 525 GHz; 125 GHz bandwidth) was utilized to acquire a 35 mm x 35 mm field-of-view with 0.5 mm x 0.5 mm pixels in less than two minutes. THz time-lapsed images were taken on three sample systems: (1) a simple binary system of water evaporating from a polypropylene towel, (2) the accumulation of fluid at the site of a sulfuric acid burn on ex vivo porcine skin, and (3) the evaporative dehydration of an ex vivo porcine cornea. The diffusion-regulating behavior of corneal tissue is elucidated, and the correlation of THz reflectivity with tissue hydration is measured using THz spectroscopy on four ex vivo corneas. We conclude that THz imaging can discern small differences in the distribution of water in physiological tissues and is a good candidate for burn and corneal imaging.

Citation Download Citation

David B. Bennett, Zachary D. Taylor, Neha Bajwa, Priyamvada Tewari, Ashkan Maccabi, Shijun Sung, Rahul S. Singh, Martin O. Culjat, Warren S. Grundfest, and Elliott R. Brown "Terahertz time-lapse imaging of hydration in physiological tissues", Proc. SPIE 7938, Terahertz Technology and Applications IV, 793808 (23 February 2011); https://doi.org/10.1117/12.882962

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