Design and development of MR-compatible SPECT systems for simultaneous SPECT-MR imaging of small animals

Benjamin M. W. Tsui; James W. Hugg; Jingyan Xu; Si Chen; Dirk Meier; William Edelstein; Abdel El-Sharkawy; Douglas J. Wagenaar; Bradley E. Patt

doi:10.1117/12.878903

16 March 2011 Design and development of MR-compatible SPECT systems for simultaneous SPECT-MR imaging of small animals

Benjamin M. W. Tsui, James W. Hugg, Jingyan Xu, Si Chen, Dirk Meier, William Edelstein, Abdel El-Sharkawy, Douglas J. Wagenaar, Bradley E. Patt

Author Affiliations +

Proceedings Volume 7961, Medical Imaging 2011: Physics of Medical Imaging; 79611Y (2011) https://doi.org/10.1117/12.878903
Event: SPIE Medical Imaging, 2011, Lake Buena Vista (Orlando), Florida, United States

Abstract

We describe a continuing design and development of MR-compatible SPECT systems for simultaneous SPECT-MR imaging of small animals. A first generation prototype SPECT system was designed and constructed to fit inside a MRI system with a gradient bore inner diameter of 12 cm. It consists of 3 angularly offset rings of 8 detectors (1"x1", 16x16 pixels MR-compatible solid-state CZT). A matching 24-pinhole collimator sleeve, made of a tungsten-compound, provides projections from a common FOV of ~25 mm. A birdcage RF coil for MRI data acquisition surrounds the collimator. The SPECT system was tested inside a clinical 3T MRI system. Minimal interference was observed on the simultaneously acquired SPECT and MR images. We developed a sparse-view image reconstruction method based on accurate modeling of the point response function (PRF) of each of the 24 pinholes to provide artifact-free SPECT images. The stationary SPECT system provides relatively low resolution of 3-5 mm but high geometric efficiency of 0.5- 1.2% for fast dynamic acquisition, demonstrated in a SPECT renal kinetics study using Tc-99m DTPA. Based on these results, a second generation prototype MR-compatible SPECT system with an outer diameter of 20 cm that fits inside a mid-sized preclinical MRI system is being developed. It consists of 5 rings of 19 CZT detectors. The larger ring diameter allows the use of optimized multi-pinhole collimator designs, such as high system resolution up to ~1 mm, high geometric efficiency, or lower system resolution without collimator rotation. The anticipated performance of the new system is supported by simulation data.

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Benjamin M. W. Tsui, James W. Hugg, Jingyan Xu, Si Chen, Dirk Meier, William Edelstein, Abdel El-Sharkawy, Douglas J. Wagenaar, and Bradley E. Patt "Design and development of MR-compatible SPECT systems for simultaneous SPECT-MR imaging of small animals", Proc. SPIE 7961, Medical Imaging 2011: Physics of Medical Imaging, 79611Y (16 March 2011); https://doi.org/10.1117/12.878903

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