16 March 2011 Effect of de-noising and DDRV correction on cone-beam SPECT reconstruction with non-uniform attenuation
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Abstract
SPECT (single photon emission computed tomography) is a non-invasive, cost-effective means for assessment of tissue/organ functions in nuclear medicine. For more accurate diagnosis, quantitative reconstruction of radiotracer concentration at any location inside the body is desired. To achieve this goal, we have to address a number of factors that significantly degrade the acquired projection data. The cone-beam SPECT system has higher resolution comparing with parallel-beam and fan-beam SPECT, which is highly advantageous in small object detection. In this paper, we used four analytical reconstruction schemes for cone-beam SPECT that allow simultaneous compensation for non-uniform attenuation and distance-dependent resolution variation (DDRV), as well as accurate treatment of Poisson noise. The simulation results show that the reconstruction scheme 1 and 4 both can obtain good reconstruction results.
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Hao Zhang, Junhai Wen, Wen Yin, Cuifen Li, Kangping Zhang, and Zhengrong Liang "Effect of de-noising and DDRV correction on cone-beam SPECT reconstruction with non-uniform attenuation", Proc. SPIE 7961, Medical Imaging 2011: Physics of Medical Imaging, 796142 (16 March 2011); doi: 10.1117/12.877352; https://doi.org/10.1117/12.877352
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