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1 March 2011 3D imaging of myocardial perfusion and coronary tree morphology from a single rotational angiogram
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Abstract
Diagnosis and treatment of coronary heart disease are performed in the catheter laboratory using an angiographic X-ray C-arm system. The morphology of the coronary tree and potentially ischemic lesions are determined in 2D projection views. The hemodynamic impact of the lesion would be valuable information for treatment decision. Using other modalities for functional imaging is disrupting the clinical workflow since the patient has to be transferred from the catheter laboratory to another scanner, and back to the catheter laboratory for performing the treatment. In this work a novel technology is used for simultaneous 3D imaging of first pass perfusion and the morphology of the coronary tree from a single rotational angiogram. A selective, single shot of contrast agent of less than 20ml directly into the coronaries is sufficient for a proper contrast resolution. Due to the long acquisition time cardiac motion has to be considered. A novel reconstruction technique for estimation and compensation of cardiac motion from the acquired projection data is used. The overlay of the 3D structure of the coronary tree and the perfusion image shows the correlation of myocardial areas and the associated coronary sections supporting that region. In a case example scar lesions caused by a former myocardial infarct are investigated. A first pass perfusion defect is found which is validated by a late enhancement magnetic resonance image. No ischemic defects are found. The non vital regions are still supported by the coronary vasculature.
© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Günter Lauritsch, Christopher Rohkohl, Joachim Hornegger, Anil-Martin Sinha, Johannes Brachmann, Johannes Rieber, and Harald Rittger "3D imaging of myocardial perfusion and coronary tree morphology from a single rotational angiogram", Proc. SPIE 7964, Medical Imaging 2011: Visualization, Image-Guided Procedures, and Modeling, 79641Q (1 March 2011); https://doi.org/10.1117/12.877931
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