9 March 2011 In vivo heterogeneous tomographic bioluminescence imaging via a higher-order approximation forward model
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Abstract
In vivo bioluminescence imaging (BLI) has played a more and more important role in biomedical research of small animals. Tomographic bioluminescence imaging (TBI) further translates the BLI optical information into three-dimensional bioluminescent source distribution, which could greatly facilitate applications in related studies. Although the diffusion approximation (DA) is one of the most widely-used forward models, higher-order approximations are still needed for in vivo small animal imaging. In this work, as a relatively accurate and higher-order approximation theory, a simplified spherical harmonics approximation (SPN) is applied for heterogeneous tomographic bioluminescence imaging in vivo. Furthermore, coupled with the SPN, a generalized graph cuts optimization approach is utilized, making BLT reconstructions fast and suit for the whole body of small animals. Heterogeneous in vivo experimental reconstructions via the higher-order approximation model demonstrate higher tomographic imaging quality, which is shown the capability for practical biomedical tomographic imaging applications.
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Kai Liu, Kai Liu, Jie Tian, Jie Tian, Chenghu Qin, Chenghu Qin, Xin Yang, Xin Yang, Shouping Zhu, Shouping Zhu, Dong Han, Dong Han, Ping Wu, Ping Wu, Xiaoqian Dai, Xiaoqian Dai, } "In vivo heterogeneous tomographic bioluminescence imaging via a higher-order approximation forward model", Proc. SPIE 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging, 79650C (9 March 2011); doi: 10.1117/12.878040; https://doi.org/10.1117/12.878040
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