Image-guided prostate sectioning supporting registration of graded cancerous foci from digital histopathology images to in vivo MRI: an interactive 3D visualization tool

E. Gibson; A. Fenster; C. Crukley; C. McKenzie; J. A. Gomez; M. Moussa; G. Bauman; A. D. Ward

doi:10.1117/12.877468

9 March 2011 Image-guided prostate sectioning supporting registration of graded cancerous foci from digital histopathology images to in vivo MRI: an interactive 3D visualization tool

E. Gibson, A. Fenster, C. Crukley, C. McKenzie, J. A. Gomez, M. Moussa, G. Bauman, A. D. Ward

Author Affiliations +

Proceedings Volume 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging; 79650D (2011) https://doi.org/10.1117/12.877468
Event: SPIE Medical Imaging, 2011, Lake Buena Vista (Orlando), Florida, United States

Abstract

Personalized treatment of prostate cancer would be enhanced by an assessment of cancer stage and grade from imaging, the validation of which requires the accurate co-registration of in vivo images with a gold standard for stage and grade established by histopathology. We present a visualization tool supporting an image-guided approach enabling the acquisition of histopathology images parallel to the in vivo imaging planes, simplifying this registration. This tool decreases imaging-to-specimen landmark alignment error by 62%, and decreases the time required to mark the slicing plane on the specimen by 47%. Preliminary results from our method demonstrate the alignment of regions suspicious for cancer on T2w MRI with confirmed cancer foci on histopathology, and we calculate a sub-millimeter in-plane target registration error.

Citation Download Citation

E. Gibson, A. Fenster, C. Crukley, C. McKenzie, J. A. Gomez, M. Moussa, G. Bauman, and A. D. Ward "Image-guided prostate sectioning supporting registration of graded cancerous foci from digital histopathology images to in vivo MRI: an interactive 3D visualization tool", Proc. SPIE 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging, 79650D (9 March 2011); https://doi.org/10.1117/12.877468

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available