9 March 2011 Image-guided prostate sectioning supporting registration of graded cancerous foci from digital histopathology images to in vivo MRI: an interactive 3D visualization tool
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Abstract
Personalized treatment of prostate cancer would be enhanced by an assessment of cancer stage and grade from imaging, the validation of which requires the accurate co-registration of in vivo images with a gold standard for stage and grade established by histopathology. We present a visualization tool supporting an image-guided approach enabling the acquisition of histopathology images parallel to the in vivo imaging planes, simplifying this registration. This tool decreases imaging-to-specimen landmark alignment error by 62%, and decreases the time required to mark the slicing plane on the specimen by 47%. Preliminary results from our method demonstrate the alignment of regions suspicious for cancer on T2w MRI with confirmed cancer foci on histopathology, and we calculate a sub-millimeter in-plane target registration error.
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E. Gibson, A. Fenster, C. Crukley, C. McKenzie, J. A. Gomez, M. Moussa, G. Bauman, A. D. Ward, "Image-guided prostate sectioning supporting registration of graded cancerous foci from digital histopathology images to in vivo MRI: an interactive 3D visualization tool", Proc. SPIE 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging, 79650D (9 March 2011); doi: 10.1117/12.877468; https://doi.org/10.1117/12.877468
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