9 March 2011 Magnetization spectroscopy of biocompatible magnetite (Fe3O4) nanoparticles for MPI
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Abstract
We report the use of a nanoparticle magnetization spectrometer to measure the suitability of magnetite nanoparticles for magnetic particle imaging (MPI). The spectrometer, which measures the strength of harmonics in the magnetization of magnetic nanoparticles, produces a driving field at 25 kHz and measures up to 40 harmonics (1Mhz bandwidth). Large, uniform, single-core magnetite particles with diameter ranging from 17 to 22 nm were synthesized for this work and their magnetization spectra were compared with a commercially available option, Resovist. The driving field amplitude was varied and spectra were acquired for field amplitudes ranging from 9.7 to 18.6 mTμ0-1. Compared with Resovist, synthesized particles showed increased harmonic power over the full measured frequency range at each driving field.
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R. Matthew Ferguson, Amit P. Khandhar, Kannan M. Krishnan, "Magnetization spectroscopy of biocompatible magnetite (Fe3O4) nanoparticles for MPI", Proc. SPIE 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging, 79650W (9 March 2011); doi: 10.1117/12.878321; https://doi.org/10.1117/12.878321
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