15 March 2011 Chemical binding affinity estimation using MSB
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Abstract
Binding affinity can be estimated in several ways in the laboratory but there is no viable way to estimate binding affinity in vivo without assumptions on the number of binding sites. Magnetic spectroscopy of nanoparticle Brownian motion, MSB, measures the rotational Brownian motion. The MSB signal is affected by nanoparticle binding affinity so it provides a mechanism to measure the chemical binding affinity. We present a possible mechanism to quantify the binding affinity and test that mechanism using viscous solutions.
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John B. Weaver, John B. Weaver, Adam M. Rauwerdink, Adam M. Rauwerdink, } "Chemical binding affinity estimation using MSB", Proc. SPIE 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging, 79650Y (15 March 2011); doi: 10.1117/12.878788; https://doi.org/10.1117/12.878788
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