15 March 2011 Altered cortical anatomical networks in temporal lobe epilepsy
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Temporal lobe epilepsy (TLE) is one of the most common epilepsy syndromes with focal seizures generated in the left or right temporal lobes. With the magnetic resonance imaging (MRI), many evidences have demonstrated that the abnormalities in hippocampal volume and the distributed atrophies in cortical cortex. However, few studies have investigated if TLE patients have the alternation in the structural networks. In the present study, we used the cortical thickness to establish the morphological connectivity networks, and investigated the network properties using the graph theoretical methods. We found that all the morphological networks exhibited the small-world efficiency in left TLE, right TLE and normal groups. And the betweenness centrality analysis revealed that there were statistical inter-group differences in the right uncus region. Since the right uncus located at the right temporal lobe, these preliminary evidences may suggest that there are topological alternations of the cortical anatomical networks in TLE, especially for the right TLE.
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Bin Lv, Bin Lv, Huiguang He, Huiguang He, Jingjing Lu, Jingjing Lu, Wenjing Li, Wenjing Li, Dai Dai, Dai Dai, Meng Li, Meng Li, Zhengyu Jin, Zhengyu Jin, } "Altered cortical anatomical networks in temporal lobe epilepsy", Proc. SPIE 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging, 79652F (15 March 2011); doi: 10.1117/12.877808; https://doi.org/10.1117/12.877808

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