15 March 2011 Sensitivity improvement of a molecular imaging technique based on magnetic nanoparticles
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Magnetic particle imaging (MPI) using the nonlinear interaction between internally administered magnetic nanoparticles (MNPs) and electromagnetic waves irradiated from outside of the body has attracted attention for the early diagnosis of diseases such as cancer. In MPI, the local magnetic field distribution is scanned, and the magnetization signal from MNPs inside an object region is detected. However, the signal sensitivity and image resolution are degraded by interference from the magnetization signal generated by MNPs that exist outside of the desired region, owing to nonlinear responses. Earlier, we proposed an image reconstruction method for suppressing the interference component while emphasizing the signal component using the property of the higher harmonic components generated by the MNPs. However, edge areas in the reconstructed image were emphasized excessively owing to the high-pass-filter effect of this method. Here, we propose a new method based on correlation information between the observed signal and a system function. We performed a numerical analysis and found that, although the image was somewhat blurred, the detection sensitivity can clearly be improved without the inverse-matrix operation used in conventional image reconstruction.
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Yasutoshi Ishihara, Yasutoshi Ishihara, Tsuyoshi Kuwabara, Tsuyoshi Kuwabara, Naoki Wadamori, Naoki Wadamori, } "Sensitivity improvement of a molecular imaging technique based on magnetic nanoparticles", Proc. SPIE 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging, 79652J (15 March 2011); doi: 10.1117/12.878127; https://doi.org/10.1117/12.878127

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