4 March 2011 New synchronous detection approach in optical transmission imaging
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Proceedings Volume 7998, International Conference on Laser Physics 2010; 799814 (2011) https://doi.org/10.1117/12.891718
Event: International Conference on Laser Physics 2010, 2010, Ashtarak, Armenia
Abstract
The key problems of optical transmission imaging of thick complex biological objects are strong diffusion (scattering) and non-uniform intensity distribution of transmitted signal across the scanned area. These constraints essentially reduce the spatial resolution and uniformity of the overall pattern. We report on implementation of a new approach of signal detection scheme, which relies on synchronization of lock-in amplifier with a temporal step of laser beam discrete scanning. This technique is favorable for preferential detection of abrupt spatial features, increase of contrast and substantial reduction of overall non-uniformity of image brightness. On the other hand, the lock-in detection scheme, being phase-sensitive, helps to some extent to enhance the contribution of least-deflected photons in the recorded signal thus suppressing the diffusion component. We present the results of measurements showing efficiency of the proposed scheme.
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Karen Z. Vardanyan, Anna A. Khachaturova, Sargis M. Varzhapetyan, Anahit M. Badalyan, Svetlana V. Shmavonyan, Aram V. Papoyan, "New synchronous detection approach in optical transmission imaging", Proc. SPIE 7998, International Conference on Laser Physics 2010, 799814 (4 March 2011); doi: 10.1117/12.891718; https://doi.org/10.1117/12.891718
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