Determination of stereoisomer in sugars by THz-TDS

S. Yamauchi; Y. Imai; H. Yokota; M. Tonouchi

doi:10.1117/12.902044

2 November 2011 Determination of stereoisomer in sugars by THz-TDS

S. Yamauchi, Y. Imai, H. Yokota, M. Tonouchi

Proceedings Volume 8011, 22nd Congress of the International Commission for Optics: Light for the Development of the World; 80118L (2011) https://doi.org/10.1117/12.902044
Event: International Commission for Optics (ICO 22), 2011, Puebla, Mexico

Abstract

Transmission-type terahertz time-domain spectroscopy (THz-TDS) using dipole-antennas on LT-GaAs layers as THzemitter and detector with fs-fiber laser as the excitation light source was applied to determine the stereoisomer of sugars in carefully controlled environment with low humidity below 5% at 20°C. Commercially available α-D-lactose including about 4% anomer and β-D-lactose including below 30% anomer were used as stereoisomer samples. The absorption spectra of compounds by the α-D- and β-D-lactose powders with various ratios were successively deconvoluted to four spectra by Lorentzian and dependent on the composition ratio. Integrated absorptions due to α-D-lactose and β-D-lactose determined the decreasing rate (r_α) and the increasing rate (r_β) for the composition ratio of the β-D-lactose powder, because the intensities were linearly dependent on the composition ratio. The net-composition ratio of α-lactose and β-lactose in the compounds was precisely evaluated by the ratio of the integrated intensities and the value of r_β / r_α, for example, the anomer-contents in commercially available α-D-lactose and β-D-lactose powders were disclosed as 3.9% and 29.1%, respectively. The demonstrated results indicate that THz-TDS is so useful not only for precise qualitativeanalysis but also for precise quantitative-analysis of stereoisomer in sugars with partially different molecular structure such as lactose.

Citation Download Citation

S. Yamauchi, Y. Imai, H. Yokota, and M. Tonouchi "Determination of stereoisomer in sugars by THz-TDS", Proc. SPIE 8011, 22nd Congress of the International Commission for Optics: Light for the Development of the World, 80118L (2 November 2011); https://doi.org/10.1117/12.902044

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