2 June 2011 Test of a novel miniature blood pressure sensor in the coronary arteries of a swine model
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Fractional flow reserve (FFR) has proven to be very useful in diagnosis of narrowed coronary arteries. It is a technique that is used in coronary catheterization to measure blood pressure difference across a coronary artery stenosis in maximal flow. In-vivo blood pressure measurement is critical in FFR diagnosis. This paper presents a novel miniature all-optical fiber blood pressure sensor. It is based on Fabry-Perot (FP) interferometry principle. The FP cavity was fabricated by directly wet etching the fiber tip. Then, a diaphragm with well-controlled thickness was bonded to the end face of the fiber using the thermal bonding technique. Finally, the sensor was packaged with a bio-compatible and flexible coil for animal tests. A 25-50 kg Yorkshire swine model was introduced as the animal test target. The left anterior descending coronary artery (LAD) was exposed, and beyond the takeoff of the largest diagonal branch, a 3.0 mm vascular occluder was secured. Firstly, standard invasive manometry was used to obtain the blood pressure as baseline. Next, a guiding catheter was introduced into the ostium of the left main coronary artery, and the miniature blood pressure sensor was advanced into the LAD at a point beyond the vascular occlude. The blood pressure beyond the vascular occlude was recorded. The sensor successfully recorded the blood pressure at both near-end and far-end of the vascular occluder.
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Nan Wu, Nan Wu, Kai Sun, Kai Sun, Xiaotian Zou, Xiaotian Zou, Kurt Barringhaus, Kurt Barringhaus, Xingwei Wang, Xingwei Wang, "Test of a novel miniature blood pressure sensor in the coronary arteries of a swine model", Proc. SPIE 8028, Fiber Optic Sensors and Applications VIII, 80280N (2 June 2011); doi: 10.1117/12.884273; https://doi.org/10.1117/12.884273

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