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16 May 2011 Tunable wavelength interrogated sensor platform (TWIST) for point-of-care diagnostics of infectious diseases
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Abstract
The TWIST platform is an optical evanescent wave sensor which enables a label-free immunoassay-based portable instrument. The approach is based on input grating coupler sensors serving as functionalized sensing devices. Binding of the target analyte to the receptor-coated grating is detected by wavelength interrogation in the telecom spectral range. We have demonstrated that high performance volumetric sensing can be achieved using a compact, low-cost telecom laser as light source. The system footprint including light source, detectors and digitizers is compact. The platform is amenable to multiplexed operation. We demonstrated a two-output system which enables detection of an analyte with an on-chip reference signal.
© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Sonia Grego, Kristin H. Gilchrist, and Brian R. Stoner "Tunable wavelength interrogated sensor platform (TWIST) for point-of-care diagnostics of infectious diseases", Proc. SPIE 8029, Sensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring; and Biometric Technology for Human Identification VIII, 802906 (16 May 2011); https://doi.org/10.1117/12.886880
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