13 May 2011 Optimization of monolithic columns for microfluidic devices
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Monolithic columns offer advantages as solid-phase extractors because they offer high surface area that can be tailored to a specific function, fast mass transport, and ease of fabrication. Porous glycidyl methacrylate-ethylene glycol dimethacrylate monoliths were polymerized in-situ in microfluidic devices, without pre-treatment of the poly(methyl methacrylate) channel surface. Cyclohexanol, 1-dodecanol and Tween 20 were used to control the pore size of the monoliths. The epoxy groups on the monolith surface can be utilized to immobilize target-specific probes such as antibodies, aptamers, or DNA for biomarker detection. Microfluidic devices integrated with solid-phase extractors should be useful for point-of-care diagnostics in detecting specific biomarkers from complex biological fluids.
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Jayson V. Pagaduan, Weichun Yang, Adam T. Woolley, "Optimization of monolithic columns for microfluidic devices", Proc. SPIE 8031, Micro- and Nanotechnology Sensors, Systems, and Applications III, 80311V (13 May 2011); doi: 10.1117/12.884265; https://doi.org/10.1117/12.884265

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