Integration of optical devices and nanotechnology for conducting genome research

Pei-Yu Chung; Parekh Parag; Zhi Zhu; Claudine Chegini; Gregory Schultz; Weihong Tan; Peng Jiang; Christopher Batich

doi:10.1117/12.887154

12 May 2011 Integration of optical devices and nanotechnology for conducting genome research

Pei-Yu Chung, Parekh Parag, Zhi Zhu, Claudine Chegini, Gregory Schultz, Weihong Tan, Peng Jiang, Christopher Batich

Proceedings Volume 8032, Next-Generation Spectroscopic Technologies IV; 80320J (2011) https://doi.org/10.1117/12.887154
Event: SPIE Defense, Security, and Sensing, 2011, Orlando, Florida, United States

Abstract

SPR based sensing techniques utilize a spectroscopy for transducing biomolecular binding events to variations in spectra. This label-free and real-time technique has widely applied for conducting biomedical research. In this study, we present a spectroscopy-based SPR system for monitoring binding between human serum albumin and nucleic acid library. Compared with conventional SPR technique, this novel system utilizes cost-effective nanostructured arrays and a portable UV-Vis spectrometer. These advantages enable a promising development of a portable analytical device for widespread applications. Meanwhile, multispectral analysis used here also helps increase the sensitivity, and thus transducing the binding event to optical signal efficiently. The result demonstrates that this cost-effective and portable system could be applied for a future application of selecting target aptamer. Moreover, we also present surface enhanced Raman spectroscopy (SERS) on the nanostructured arrays in a label-free approach. This integration of multiple spectroscopy technologies is utilized for conducting genome research efficiently.

Citation Download Citation

Pei-Yu Chung, Parekh Parag, Zhi Zhu, Claudine Chegini, Gregory Schultz, Weihong Tan, Peng Jiang, and Christopher Batich "Integration of optical devices and nanotechnology for conducting genome research", Proc. SPIE 8032, Next-Generation Spectroscopic Technologies IV, 80320J (12 May 2011); https://doi.org/10.1117/12.887154

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