12 May 2011 Real-time smart fluorescence sensor platform
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Abstract
A novel compact LED array based light induced fluorescence (LIF) sensor has been developed for real-time in-line monitoring of intrinsic fluorophores in the solid and liquid state. The sensor is essential for on-the-spot, routine, and cost effective real-time analysis. The sensor is designed to provide real-time emission response along with various smart sensing parameters to ensure real-time measurement quality that is required for regulated GMP process monitoring applications. This work describes a LIF sensor tailored for solid-phase fluorometry. Fundamental figures of merit, excitation overexposure and smart sensing features required for modern process monitoring and control are discussed within the context of pharmaceutical solid-phase manufacturing and similar applications.
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Jason E. Dickens, Mike S. Vaughn, Mervin Taylor, Mike Ponstingl, "Real-time smart fluorescence sensor platform", Proc. SPIE 8032, Next-Generation Spectroscopic Technologies IV, 80320S (12 May 2011); doi: 10.1117/12.884533; https://doi.org/10.1117/12.884533
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