13 May 2011 Identification of biological agents using surface enhanced Raman scattering
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Abstract
GE Global Research Center, in collaboration with Morpho Detection, Inc. has developed an assay scheme for the identification of biological agents using Surface Enhanced Raman Scattering (SERS). Specifically, unique spectroscopic signatures are generated using SERS tags consisting of individual glass-encapsulated gold nanoparticles and surfacebound reporter molecules. These SERS tags are modified with a capture moiety specific to the antigen of interest, and serve as a spectroscopic label in a bead-based sandwich assay. Assays are being developed for a variety of pathogens and this paper will focus on aspects of assay development, optimization, stabilization and validation. Results on the development of an assay to detect Ricin toxin will be presented, and preliminary feasibility studies for the detection of additional pathogens will be discussed.
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Tracy L. Paxon, R. Scott Duthie, Casey Renko, Andrew A. Burns, Marie L. Lesaicherre, Frank J. Mondello, "Identification of biological agents using surface enhanced Raman scattering", Proc. SPIE 8034, Photonic Microdevices/Microstructures for Sensing III, 803403 (13 May 2011); doi: 10.1117/12.884259; https://doi.org/10.1117/12.884259
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