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14 May 2011 Integrated photonic structures for parallel fluorescence and refractive index biosensing
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Abstract
We present a multi-modality optical sensing platform employing integrated Vertical Cavity Surface Emitting Lasers (VCSELs), photodetectors, and filters suitable for portable, real-time analyte detection in aqueous environments. Fluorescence and refractive index sensors designed to utilize visible and near-infrared VCSELs for low background absorption from analyte delivery fluids are described. We demonstrate in vitro fluorescence sensing of Cy5.5 dye with a detection sensitivity of 5 nM and photonic crystal slab refractive index sensing with tunable GaAs-based 670 nm VCSELs. This compact, parallel sensor architecture enables multiplexed, cost-effective on-chip biosensing.
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Meredith M. Lee, Thomas D. O'Sullivan, Antonio Cerruto, Victor Liu, Jingyu Zhang, Ofer Levi, Heon Lee, Steven R. J. Brueck, Shanhui Fan, and James S. Harris "Integrated photonic structures for parallel fluorescence and refractive index biosensing", Proc. SPIE 8034, Photonic Microdevices/Microstructures for Sensing III, 803406 (14 May 2011); doi: 10.1117/12.884228; https://doi.org/10.1117/12.884228
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