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25 May 2011 Radiobiology with laser-accelerated quasi-monoenergetic proton beams
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Abstract
Human cancer cells are irradiated by laser-driven quasi-monoenergetic protons. Laser pulse intensities at the 5×1019-W/cm2 level provide the source and acceleration field for protons that are subsequently transported by four energy-selective dipole magnets. The transport line delivers 2.25 MeV protons with an energy spread of 0.66 MeV and a bunch duration of 20 ns. The survival fraction of in-vitro cells from a human salivary gland tumor is measured with a colony formation assay following proton irradiation at dose levels up to 8 Gy, for which the single bunch does rate is 1 × 107 Gy/s and the effective dose rate is 0.2 Gy/s for 1-Hz repetition of irradiation. Relative biological effectiveness at the 10% survival fraction is measured to be 1.20 ± 0.11 using protons with a linear energy transfer of 17.1 ± 2.8 keV/μm.
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A. Yogo, T. Maeda, T. Hori, H. Sakaki, K. Ogura, M. Nishiuchi, A. Sagisaka, P. R. Bolton, M. Murakami, S. Kawanishi, and K. Kondo "Radiobiology with laser-accelerated quasi-monoenergetic proton beams", Proc. SPIE 8079, Laser Acceleration of Electrons, Protons, and Ions; and Medical Applications of Laser-Generated Secondary Sources of Radiation and Particles, 80791D (25 May 2011); https://doi.org/10.1117/12.886680
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