The increasing deterioration of panel paintings can be due to physical processes that take place during exhibition or
transit, or as a result of temperature and humidity fluctuations within a building, church or museum. In response to
environmental alterations, a panel painting can expand or contract and a new equilibrium state is eventually reached.
These adjustments though, are usually accompanied by a change in shape in order to accommodate to the new
conditions. In this work, a holographic method for detecting detached regions and micro-cracks is described. Some of
these defects are confirmed by Thermographic Signal Reconstruction (TSR) technique. In addition, Pulsed Phase
Thermography (PPT) and Principal Component Thermography (PCT) allow to identify with greater contrast two
artificial defects in Mylar which are crucial to understand the topic of interest: the discrimination between defect
materials. Finally, traditional contact ultrasounds applications, are widely applied for the evaluation of the wood quality
in several characterization procedures. Inspecting the specimen from the front side, the natural and artificial defects of
the specimen are confirmed. Experimental results derived by the application of the integrated methods on an Italian panel
painting reproduction, called The Angel specimen, are presented. The main advantages that these techniques can offer to
the conservation and restoration of artworks are emphasized.