10 June 2011 Evaluation of haemoglobin changes of skin and muscle tissue of the calf induced by topical application of a nonivamide / nicoboxil cream
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Abstract
Topical agents inducing hyperaemisation like nonivamide or nicoboxil increase cutaneous blood flow and temperature and induce erythema. It is not proven up to now whether there is also a hyperaemisation effect in skeletal muscle. This study has the objective to determine the effects of a nonivamide / nicoboxil cream on haemodynamics in skin and calf muscle via optical spectroscopy in the visible and near-infrared with a separation of changes for skin and muscle. Left and right calves of 14 healthy subjects were treated with a nonivamide / nicoboxil cream or mock administration, and cutaneous and muscle haemoglobin were measured using a combined NIRS / VIS sensor. The topical application of the cream increased the concentration of oxygenated haemoglobin and tissue oxygen saturation significantly in skin as well as in muscle of the treated legs already after 15 minutes, with stronger and faster effects in skin. In contrast, the change in deoxygenated haemoglobin was found to be small. The kinetic of all changes varied widely between the subjects. The found haemoglobin changes might explain the beneficial effect of hyperaemisation creams for the treatment of minor injuries.
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Jan Warnecke, Thomas Wendt, Matthias Schak, Thorsten Schiffer, Wilhelm Bloch, Matthias Kohl-Bareis, "Evaluation of haemoglobin changes of skin and muscle tissue of the calf induced by topical application of a nonivamide / nicoboxil cream", Proc. SPIE 8087, Clinical and Biomedical Spectroscopy and Imaging II, 80871X (10 June 2011); doi: 10.1117/12.889329; https://doi.org/10.1117/12.889329
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