Design of a tissue oxygenation monitor and verification on human skin

Hongyuan Liu; Matthias Kohl-Bareis; Xiabing Huang

doi:10.1117/12.889197

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10 June 2011 Design of a tissue oxygenation monitor and verification on human skin

Hongyuan Liu, Matthias Kohl-Bareis, Xiabing Huang

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Proceedings Volume 8087, Clinical and Biomedical Spectroscopy and Imaging II; 80871Y (2011) https://doi.org/10.1117/12.889197
Event: European Conferences on Biomedical Optics, 2011, Munich, Germany

Abstract

We report the design of a tissue oxygen and temperature monitor. The non-invasive, fibre based device monitors tissue haemoglobin (Hb) and oxygen saturation (SO₂) and is based on white-light reflectance spectroscopy.Visible light with wavelengths in the 500 - 650nm range is utilized. The spectroscopic algorithm takes into account the tissue scattering and melanin absorption for the calculation of tissue haemoglobin concentration and oxygen saturation. The monitor can probe superficial layers of tissue with a high spatial resolution (mm³) and a high temporal resolution (40 Hz). It provides an accurate measurement with the accuracy of SO₂ at 2 % and high reliability with less than 2 % variation of continuous SO₂ measurement over 12 hours. It can also form a modular system when used in conjunction with a laser Doppler monitor, enabling simultaneous measurements of Hb, SO₂ and blood flow. We found experimentally that the influence of the source-detector separation on the haemoglobin parameters is small. This finding is discussed by Monte Carlo simulations for the depth sensitivity profile. The influence of probe pressure and the skin pigmentation on the measurement parameters are assessed before in vivo experimental data is presented. The combination with laser Doppler flowmetry demonstrates the importance of a measurement of both the haemoglobin and the blood flow parameters for a full description of blood tissue perfusion. This is discussed in experimental data on human skin during cuff occlusion and after hyperemisation by a pharmacological cream. Strong correlation is observed between tissue oxygen (Hb and SO₂) and blood flow measurements.

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Hongyuan Liu, Matthias Kohl-Bareis, and Xiabing Huang "Design of a tissue oxygenation monitor and verification on human skin", Proc. SPIE 8087, Clinical and Biomedical Spectroscopy and Imaging II, 80871Y (10 June 2011); https://doi.org/10.1117/12.889197

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