Discrimination of serum Raman spectroscopy between normal and colorectal cancer

Xiaozhou Li; Tianyue Yang; Ting Yu; Siqi Li

doi:10.1117/12.889304

14 June 2011 Discrimination of serum Raman spectroscopy between normal and colorectal cancer

Xiaozhou Li, Tianyue Yang, Ting Yu, Siqi Li

Proceedings Volume 8087, Clinical and Biomedical Spectroscopy and Imaging II; 808727 (2011) https://doi.org/10.1117/12.889304
Event: European Conferences on Biomedical Optics, 2011, Munich, Germany

Abstract

Raman spectroscopy of tissues has been widely studied for the diagnosis of various cancers, but biofluids were seldom used as the analyte because of the low concentration. Herein, serum of 30 normal people, 46 colon cancer, and 44 rectum cancer patients were measured Raman spectra and analyzed. The information of Raman peaks (intensity and width) and that of the fluorescence background (baseline function coefficients) were selected as parameters for statistical analysis. Principal component regression (PCR) and partial least square regression (PLSR) were used on the selected parameters separately to see the performance of the parameters. PCR performed better than PLSR in our spectral data. Then linear discriminant analysis (LDA) was used on the principal components (PCs) of the two regression method on the selected parameters, and a diagnostic accuracy of 88% and 83% were obtained. The conclusion is that the selected features can maintain the information of original spectra well and Raman spectroscopy of serum has the potential for the diagnosis of colorectal cancer.

Citation Download Citation

Xiaozhou Li, Tianyue Yang, Ting Yu, and Siqi Li "Discrimination of serum Raman spectroscopy between normal and colorectal cancer", Proc. SPIE 8087, Clinical and Biomedical Spectroscopy and Imaging II, 808727 (14 June 2011); https://doi.org/10.1117/12.889304

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