Using MAP to recover the optical properties of a biological tissue from reflectance measurements

Amaria Zidouk; Iain B. Styles

doi:10.1117/12.889632

15 June 2011 Using MAP to recover the optical properties of a biological tissue from reflectance measurements

Amaria Zidouk, Iain B. Styles

Proceedings Volume 8087, Clinical and Biomedical Spectroscopy and Imaging II; 80872A (2011) https://doi.org/10.1117/12.889632
Event: European Conferences on Biomedical Optics, 2011, Munich, Germany

Abstract

There exist numerous methods that aim to extract the optical parameters of a tissue by relating reflectance measurements to a theoretical model of light transport. During the parameter recovery process, assumptions are often made about the characteristics of the tissue. However, specious assumptions lead to inaccurate or even incorrect results. We present a method based on the maximum a posteriori estimation technique to recover the concentrations of the main chromophores present in a biological tissue from reflectance or transmittance measurements. The method provides correct results even in the presence of significant uncertainty in the underlying properties of the tissue. A preliminary analysis of the results obtained from simulated skin reflectance spectra suggests that the proposed MAP based method provides accurate estimates and is robust against a high level of uncertainty in the tissue's model. The results of phantom data are in agreement with the findings from our simulations as they emphasise the importance of including prior information about the unknown parameter in the estimation process.

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Amaria Zidouk and Iain B. Styles "Using MAP to recover the optical properties of a biological tissue from reflectance measurements", Proc. SPIE 8087, Clinical and Biomedical Spectroscopy and Imaging II, 80872A (15 June 2011); https://doi.org/10.1117/12.889632

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KEYWORDS

Statistical analysis

Tissues

Reflectivity

Tissue optics

Biological research

Transmittance

Dysprosium

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