20 June 2011 Towards a realistic numerical modeling of polarimetric response of healthy and pathological colon tissue
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Abstract
We present Monte Carlo simulations of the backscattering of polarized light by colon tissue in terms of Mueller matrix. We validated the Monte Carlo code with measurements on aqueous suspensions of polystyrene spheres of different sizes. In a first instance we have modeled a tissue as a monodisperse scattering medium representing the nuclei in cytoplasm; then we included a second layer with monodisperse scatterers to represent the most superficial layers (mucosa and submucosa) while the deeper layers (muscularis and pericolic tissue) were "lumped" into a totally depolarizing lambertian. These simulations failed to reproduce the Rayleigh type scattering (larger depolarization for circular vs. linear incident polarization) systematically observed on all experimentally studied tissue samples. This issue has been solved by modelling tissues as a single layer of bimodal mixtures including large and small scatterers over a lambertian.
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Maria Rosaria Antonelli, Angelo Pierangelo, Tatiana Novikova, Pierre Validire, Abdelali Benali, Brice Gayet, Antonello De Martino, "Towards a realistic numerical modeling of polarimetric response of healthy and pathological colon tissue", Proc. SPIE 8087, Clinical and Biomedical Spectroscopy and Imaging II, 80872U (20 June 2011); doi: 10.1117/12.896635; https://doi.org/10.1117/12.896635
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