Toward absolute quantification in CW-FDOT systems: use of a priori information

Anne Planat-Chrétien; Anne Koenig; Jean-Guillaume Coutard; Lionel Hervé; Marco Brambilla; Jean-Marc Dinten

doi:10.1117/12.889583

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14 June 2011 Toward absolute quantification in CW-FDOT systems: use of a priori information

Anne Planat-Chrétien; Anne Koenig; Jean-Guillaume Coutard; Lionel Hervé; Marco Brambilla; Jean-Marc Dinten

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Proceedings Volume 8088, Diffuse Optical Imaging III; 80880W (2011) https://doi.org/10.1117/12.889583
Event: European Conferences on Biomedical Optics, 2011, Munich, Germany

Abstract

In the context of continuous wave fluorescence-enhanced diffuse optical tomography, we show that the reconstructed fluorescence depends on the local diffusion coefficient and demonstrate that the a priori knowledge of specific optical parameters may lead to the reconstruction of absolute quantification of the fluorophore distribution. In this context, we point out the potentiality of a bimodal instrument coupling functional and morphological information to provide knowledge of the distribution of optical parameters of internal organs. We show some quantitative results on simulated and experimental data on phantoms and conclude suggesting the use of optical parameters atlases to achieve an absolute quantification of fluorophore distribution in real contexts.

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Anne Planat-Chrétien, Anne Koenig, Jean-Guillaume Coutard, Lionel Hervé, Marco Brambilla, and Jean-Marc Dinten "Toward absolute quantification in CW-FDOT systems: use of a priori information", Proc. SPIE 8088, Diffuse Optical Imaging III, 80880W (14 June 2011); https://doi.org/10.1117/12.889583

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