14 June 2011 Development of image reconstruction algorithms for fluorescence diffuse optical tomography using total light approach
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Abstract
Fluorescence diffuse optical tomography (FDOT) based on the total light approach is developed. The continuous wave light is used for excitation in this system. The reconstruction algorithm is based on the total light approach that reconstructs the absorption coefficients increased by the fluorophore. Additionally we propose noise reduction using the algebraic reconstruction technique (ART) incorporating the truncated singular value decomposition (TSVD). Numerical and phantom experiments show that the developed system successfully reconstructs the fluorophore concentration in the biological media, and the ART with TSVD alleviates the influence of noises. In vivo experiment demonstrated that the developed FDOT system localized the fluorescent agent which was concentrated in the cancer transplanted into a kidney in a mouse.
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S. Okawa, H. Yamamoto, Y. Miwa, Y. Yamada, "Development of image reconstruction algorithms for fluorescence diffuse optical tomography using total light approach", Proc. SPIE 8088, Diffuse Optical Imaging III, 80880X (14 June 2011); doi: 10.1117/12.889958; https://doi.org/10.1117/12.889958
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