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1 June 2011Mechanical compression
for contrasting OCT images of biotissues
Contrasting of biotissue layers in OCT images after application of mechanical compression is discussed. The study is
performed on ex vivo samples of human rectum, and in vivo on skin of human volunteers. We show that mechanical
compression provides contrasting of biotissue layer boundaries due to different mechanical properties of layers. We
show that alteration of pressure from 0 up to 0.45 N/mm2 causes contrast increase from 1 to 10 dB in OCT imaging of
human rectum ex vivo. Results of ex vivo studies are in good agreement with Monte Carlo simulations. Application of
pressure of 0.45 N/mm2 causes increase in contrast of epidermis-dermis junction in OCT-images of human skin in vivo
for about 10 dB.
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Mikhail Yu Kirillin, Pavel D. Argba, Vladislav A. Kamensky, "Mechanical compression for contrasting OCT images of biotissues," Proc. SPIE 8091, Optical Coherence Tomography and Coherence Techniques V, 80910N (1 June 2011); https://doi.org/10.1117/12.889844