8 June 2011 Resolution limits between objects embedded in breast-like slab using the optical frequency-domain method: a numerical approach
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Abstract
Optical methods allow investigating biological tissue noninvasively without ionizing radiations. Moreover, considering low absorption processes in the tissue in the near-infrared wavelengths range, biological tissue can be deeply investigated. In this field, we studied the resolution limits of the detection of one and two tumour-like heterogeneities embedded in the middle plane of a slab that mimics a breast enclosed between two transparent plates. We used the diffusion equation in order to model the photons propagation in such slab. It is solved in the time-domain by means of a finite element method. We computed time-resolved trans-illumination data based on lateral scan of the slab. The timedependent transmitted light, received at the opposite of the source, was transformed in the frequency-domain and the modulation and phase-shift of the signal are then obtained. The resulting phase-shift considering the embedded objects was analyzed versus the distance between the objects. Then, the resolution limits were estimated considering different modulation frequencies and a noise level. The overall combinations took into account a set of optical properties that mimics realistic optical properties for healthy breast tissue and tumours.
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Vianney Piron, Vianney Piron, Jean-Pierre L'Huillier, Jean-Pierre L'Huillier, } "Resolution limits between objects embedded in breast-like slab using the optical frequency-domain method: a numerical approach", Proc. SPIE 8092, Medical Laser Applications and Laser-Tissue Interactions V, 80920O (8 June 2011); doi: 10.1117/12.890002; https://doi.org/10.1117/12.890002
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