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2 June 2011 Monte Carlo simulation of photon way in clinical laser therapy
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Abstract
The multiple scattering of light can increase efficiency of laser therapy of inflammatory diseases enlarging the treated area. The light absorption is essential for treatment while scattering dominates. Multiple scattering effects must be introduced using the Monte Carlo method for modeling light transport in tissue and finally to calculate the optical parameters. Diffuse reflectance measurements were made on high concentrated live leukocyte suspensions in similar conditions as in-vivo measurements. The results were compared with the values determined by MC calculations, and the latter have been adjusted to match the specified values of diffuse reflectance. The principal idea of MC simulations applied to absorption and scattering phenomena is to follow the optical path of a photon through the turbid medium. The concentrated live cell solution is a compromise between homogeneous layer as in MC model and light-live cell interaction as in-vivo experiments. In this way MC simulation allow us to compute the absorption coefficient. The values of optical parameters, derived from simulation by best fitting of measured reflectance, were used to determine the effective cross section. Thus we can compute the absorbed radiation dose at cellular level.
© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Iulian Ionita and Gabriel Voitcu "Monte Carlo simulation of photon way in clinical laser therapy", Proc. SPIE 8092, Medical Laser Applications and Laser-Tissue Interactions V, 80920X (2 June 2011); doi: 10.1117/12.889989; https://doi.org/10.1117/12.889989
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